Paper Information

Title: 

INVESTIGATION OF INTERACTION BETWEEN URB597 AND ISOGUVACINE ON PENTYLENETETRAZOLE-INDUCED SEIZURE IN RAT

Type: POSTER
Author(s): AHMAD MOULAEI L.,AZIZ AHARI F.,NADERI NIMA,MOTAMEDI F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Based on the results of previous studies, both the cannabinoidergic and GABAergic systems are involved in seizure mechanism. The aim of this study was to investigate the role of endocannabinoid degradation enzyme inhibitor URB597 on anti-seizure effect of GABA-A receptor agonist isoguvacine (IGN) using pentylenetetrazole (PTZ) model of seizure in rats. Male Wistar rats weighting 220- 280 were divided randomly into 13 groups. Intracerebroventricular microinjection of URB597 (10, 25 and 50μg/5μl) or isoguvacine (5, 10, 30 and 50μg/5μl) was done 20 min before a single dose of PTZ (90 mg/kg, i.p.), then animals were placed in chambers for close observation of behavioral seizure activities for 30 min. Administration of IGN (5μg/5μl) but not URB597significantly increased the latency of seizure occurrence compared with control group. Furthermore, Coadministration of URB597 and IGN did not produce any interaction in anti-seizure activity of IGN. The results showed that administration of URB597 could not alter the anticonvulsant effect of IGN.

 
Keyword(s): CANNABINOIDS, GABA-A RECEPTOR, ANTICONVULSANT EFFECT, PTZ-INDUCED SEIZURE MODEL, RAT
 
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