Paper Information

Title: 

INTERACTION BETWEEN WIN55, 212-2 AND ISOGUVACINE ON PENTYLENETETRAZOL-INDUCED SEIZURE IN RAT

Type: POSTER
Author(s): AZIZ AHARI F.*,AHMAD MOULAEI L.,NADERI NIMA,MOTAMEDI F.
 
 *NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Several lines of studies have shown that Cannabinoids produce anticonvulsant properties in a variety of seizure models in animals. The anticonvulsant properties of cannabinoid compounds might be in part through their effect on excitatory and inhibitory neurotransmission in CNS. In this study we investigated the effect of either cannabinoid receptor agonist WIN55212-2 or GABA-A receptor agonist isoguvacine (IGN) alone or in combination on pentylenetetrazole (PTZ)-induced seizure in rats. Animals received Intracerebroventricular microinjection of different doses of drugs 20 min before receiving a single dose of PTZ (90 mg/kg; i.p.) then were observed for 30 min for the signs of tonic-clonic seizure. Administration of WIN55212-2 (3, 10 and 30μg/5μl) or isoguvacine (5μg/5μl) significantly increased the latency of seizure occurrence compared to control group. Moreover, coadministration of WIN55212-2 (30μg/5μl) and isoguvacine (30μg/5μl) significantly decreased the latency of seizure occurrence compared with groups received WIN55212-2 (30μg/5μl) or isoguvacine (30μg/5μl) alone. Our results indicated that although WIN55212-2 and isoguvacine have anticonvulsant effect per se, however, co-administration of these compounds can attenuate their anticonvulsant effect in PTZ-induced seizure model of rats.

 
Keyword(s): CANNABINOIDS, GABA-A RECEPTOR, ANTICONVULSANT EFFECT, PTZ-INDUCED SEIZURE MODEL, RAT
 
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