Paper Information

Title: 

EFFECT OF LITHIUM ON ALLODYNIA IN RAT NEUROPATHIC PAIN MODEL; ROLE OF OPIOID SYSTEM

Type: POSTER
Author(s): BANAFSHEH H.R.*,HAMIDI GH.A.,MESDAGHINIA A.,HONARKAR RAMEZANI M.,NOURANI ARANI M.
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Neuropathic pain is chronic pain that cause by nerve injury in peripheral or central nervous system. Lithium is major drug for bipolar disorder and mania. Recently, many studies have shown the neuroprotective effect of lithium and also interaction of lithium and opioid system has been reported. Therefore, the Effect of Lithium on rat neuropathic pain model and role of opioid system was studied. The neuropathic pain was produced by partial ligating of sciatic nerve and experiments were conducted in one control group that underwent the surgical procedure, except sciatic nerve ligation and five test group; saline, lithium (5, 10 and 15 mg/kg, i.p.) and naloxane (1mg/kg. i.p.) and finally one group receive naloxane (1mg/kg. i.p.), 15 minutes to injection of lithium (10mg/kg). Mechanical and cold allodynia were assayed 5, 7, 10 and 14 days after surgery. The data were analyzed by repeated measure ANOVA. Lithium (10 and 15mg/kg) decreased allodynia score significantly (P<0.01). Naloxane (1mg/kg) did not change allodynia score in control and lithium (10mg/kg) group significantly (P>0.05). Our results showed the analgesic effect of lithium in neuropathic pain model without involvement of opioid system.

 
Keyword(s): LITHIUM, NEUROPATHIC PAIN, OPIOID, RAT
 
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