Paper Information

Title: 

EVALUATION OF INTERFERENCE BETWEEN CANABINERGIC AND DOPAMINERGIC SYSTEMS IN CENTRAL AMYGDALE ON ANXITY BY ELEVATED PLUS MAZE MODEL IN RATS

Type: SPEECH
Author(s): MAHBOUBI S.*,ZARINDAST M.R.,ORYAN SHAHRBANOU,SHIRAZI M.A.S.
 
 *SCHOOL OF BIOLOGY, OLOUM TAHGHIGHAT UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In this study, the effect of the agonist and antagonist of D1 and D2 Dopamine receptors on the CB1 Canabinoid receptor response in Amygdale area has been investigated by "Elevated Plus Maze". Elevated Plus Maze is one of the most useful animal models in anxiety studies. The results of this study demonstrated that Intra Amygdale administration of ACPA (the agonist of CB1 Canabinoid receptor) and Apomorphine (the agonist of Dopamine receptor) has decreased anxiety in Elevated Plus Maze. Also Intra Amygdale administration of SCH23390 and Sulpiride (antagonists of Dopamine receptors) has decreased anxiety in Elevated Plus Maze. Furthermore, Canabinergic and Dopaminergic systems interfere in anxiety behaviors, and this interference is mediated through D1 and D2 Dopamine receptors. Also APCA reduces anxiety via these two receptors.

 
Keyword(s): CANABINOID RECEPTOR, DOPAMINE RECEPTORS, AMYGDALE, ELEVATED PLUS MAZE, ANXIETY
 
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