Paper Information

Title: 

PRETREATMENT EFFECTS OF PIPERINE ON MORPHINE- INDUCED ANALGESIA

Type: POSTER
Author(s): BABAZADEH N.*,TAYEBI E.,HASHEMI MARIA,MOGHADAMNIA ALI AKBAR
 
 *PHARMACOLOGY GROUP
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Piperine is an alkaloid derived from black pepper and a lot of research have been done regarding to its analgesic and anti-inflammatory effects. The effect piperine pretreatment on morphine analgesia was examined in the present study. The mice were divided into 2 groups, piperine (15 and 30 mg/kg, i.p.) pre-treatment morphine (20 and 30 mg/kg) and salinepretreatment morphine. The baseline tolerances of all groups were measured by hot plate method (53-54oC, cut-off time; 40sec). One hour after the initial injection (piperine and/or saline), mice pain tolerance was measured in 6 steps and during the times of 15 minutes by hot plate method. Results showed that piperine-saline group did not show any significant increase in analgesia in comparison to saline-saline group. But piperine-morphine groups showed a significant difference in increasing analgesia in comparison to morphine-saline (P<0.05). Piperine (30mg/kg)-morphine had significant increase compared with piperine (15mg/kg)-morphine. There was no significant difference between effects of two doses of morphine. In conclusion, Piperine does not have analgesic effect by itself, but can dose-dependently increase the effect of morphine.

 
Keyword(s): MORPHINE, PIPERINE, ANALGESIA
 
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