Paper Information

Title: 

EFFECT OF ALCOHOLIC-AQUAEUS BRASSICA NIGRA EXTRACT ON PTZ-INDUCED CONVULSION KINDLING MODEL OF MALE MICE

Type: POSTER
Author(s): SADEGHIAN A.*,KIASALARI Z.,KHALILI M.
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, SHAHED UNIVESITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Regarding incidence of epilepsy in human society and respecting insufficient therapies, the new strategy and methods are recommended for medical treatment of epilepsy patients. Brassica Nigra, a medicinal plant which has been used in traditional medicine as a sedative of neurotic pains, elimanting cerebral asphyxia and for treatment of epilepsy treatment. So the present study was designed to investigate its anticonvulstant effect experimentally using kindling method. In the present study 60 male mice were randomly selected and divided into 6 groups (n=10 in each group) 1) Control 2) Sham (received saline as vehicle) 3, 4 and 5) treatment (received the extract in three doses of 75, 150 and 300 mg/kg; i.p.) 6) Positive control which received Valperoic acid (100 mg/kg) as anti-convulsant drug. All groups were kindled by 11 period injection of PTZ (35 mg/kg; i.p.).Each administration was done in 48 h and 11 injections during 22 days. However the exhibited phases of seizure (0-5) were observed and noted till 30 min after PTZ injection. Our data analysis showed that the Brassica Niger extract in lower dose could significantly eliminate the exhibition duration time of phase 5 seizure. However the efficacy of the extract was shown from 7th PTZ injection and reached to maximum in 12th (Challenge dose) injection. The attained results show that the alcoholic extract of Brassica Niger could eliminateepileptic seizure induced by PTZ in male mice.

 
Keyword(s): EPILEPSY, BRASSICA NIGRA, MICE, CHEMICAL KINDLIN
 
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