Paper Information

Title: 

THE DIFFERENCE OF ANALGESIC EFFECT AND TOLERANCE TO MORPHINE BETWEEN MALE AND FEMALE MICE

Type: POSTER
Author(s): KHATAMI L.*,KHODA BANDEHLOU F.,KARAMI REZA,HOSSEINI MAHMOUD
 
 *DEPARTMENT OF PHYSIOLOGY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Sex-dependent changes of behavioral responses of humans and animals have been widely investigated. There are also controversial reports regarding the role of sex hormones in pain and analgesic effects of morphine. In the present study morphine tolerance and its analgesic effect in male and female mice was investigated. Twenty mice were divided into male and female groups. Hot plate test was carried out as a base record, then the animals received 10 mg/kg (S.C.) morphine and antinociceptive effect was evaluated every 15 min. Morphine tolerance was induced by injection of 30 mg/kg morphine, 3 times a day, during 4 consecutive days. Finally, the analgesic effect of morphine was evaluated after injection of morphine (10 mg/kg). Before morphine tolerance, the reaction times after injection of morphine (10mg/kg) was longer than base time in both female and male groups while after tolerance induction, there was no difference between base time and reaction times. All reaction times after injection of morphine in male group were more than female group. there was no significant difference in reaction times in both male and female tolerated animals after injection of 10 mg/kg of morphine. The result showed that repeated administration of morphine can lead to tolerance. Analgesic effect of morphine in male mice was higher than female however; there were no differences between male and female animals in tolerance.

 
Keyword(s): MICE, MALE, FEMALE, PAIN, TOLERANCE
 
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