Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

INTERACTION OF CB1CANNABINOID RECEPTOR AND OPIOID SYSTEM IN ANXIETY IN RAT

Type: POSTER
Author(s): SARAHROUDI SH.*,ARZI ARDESHIR,ZARINDAST M.R.,TAHERI SHALMANI S.
 
 *SCHOOL OF MEDICINE, QOM UNIVERSITY OF MEDICAL SCIENCES, QOM, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Mood and anxiety disorders, are the most prevalent of the psychiatric disorders, cause immeasurable suffering worldwide. Previous studies have suggested that cannabinergic system is involved in anxiety, and there are functional interactions between the cannabinoid and opioid systems. On the other hand, it has been shown that the central amygdala (CeA) has an important role in the integration and expression of fear and anxiety. In this study we investigated the effects of intraperitoneal (i.p.) injection of opioid drugs on responses induced by intracentral amygdala (intra-CeA) microinjection of cannabinoid CB1 receptor agents in rats, using the elevated plus maze test of anxiety. I.p. injection of morphine (6 and 9 mg/kg) showed an anxiolytic effect by increasing %open arm time (%OAT) and %open arm entries (%OAE) in the EPM and I.p. administration of the opioid receptor antagonist, naloxone (1 mg/kg) increased anxiety by decreasing %OAT and%OAE. Intra-CeA administration of ACPA, a CB1 receptor agonist (1.25 and 5 ng/rat) increased %OAT and %OAE, indicating an anxiolytic effect. Co-administration of morphine (6 mg/kg, i.p.) plus ACPA (0.125ng/rat, intra-CeA) increased the anxiolytic-like response, and administration of naloxone reversed the effects of intra- CeA injection of ACPA. Intra-CeA administration of the cannabinoid CB1 receptor antagonist, AM251 (2.5, 25, and 100 ng/rat) did not alter %OAT and %OAE, also coadministration of morphine (6 mg/kg) or naloxone (0.1 mg/kg) with AM251 showed an anxiolytic like response. In conclusion, the results may indicate an anxiolytic-like effect for cannabinoid CB1 receptors of the CeA and the existence of an interaction between the cannabinoid and the opioid systems in the modulation of anxiety.

 
Keyword(s): ANXIETY, ELEVATED PLUS MAZE, CANNABINOIDS, OPIOIDS
 
 
Yearly Visit 39   tarjomyar
 
Latest on Blog
Enter SID Blog