Paper Information

Title: 

THE EFFECTS OF URB597, FATTY ACID AMIDE HYDROLASE (FAAH) INHIBITOR, IN THE BASOLATERAL AMYGDALA OF RAT ON ANXIETY-LIKE BEHAVIORS

Type: POSTER
Author(s): HAJIZADEH MOGHADAM A.*,DAMCHI JELOUDAR J.,KHOSRAVI MARYAM,ROUHBAKHSH A.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF BASIC SCIENCE, UNIVERSITY OF MAZANDARAN, BABOLSAR, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

There are reports indicating that cannabinoid system may change anxietyrelated behaviours. Cannabinoid CB1 receptors are particularly concentrated in limbic structures such as the hippocampus and amygdala suggesting that endocannabinoids may contribute to learning, memory and anxiety. Amygdala complex is an important brain site in the modulation of fear- or anxiety-like behaviors. The effects of bilateral intra-basolateral amygdala (Intra-BLA) injection of URB597, FAAH inhibitor, and AM251, selective CB1 receptor antagonist, on anxiety-related behaviors using elevated plus-maze test of anxiety were evaluated in the present study. Injection of URB597 at the doses of 0.001, 0.005 and 0.01μg/rat showed a significant anxiolytic effect at 0.005 and 0.01μg/rat. Moreover, intra-BLA injection of AM251 at the doses of 0.001, 0.01 and 0.1μg/rat produced anxiogenic effect in the elevated plus-maze at doses 0.01 μg/rat. The ineffective doses of AM251 (0.01 μg/rat) on anxiety-related behaviors were injected with URB597. The obtained data showed that AM251 could reverse the anxiogenic effect of URB597. Our results indicated that endocannabinoid system in the basolateral amygdala may modulate anxiety-like behaviors through CB1 receptor.

 
Keyword(s): BASOLATERAL AMYGDALA, ENDOCANNABINOID, ANXIETY
 
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