Paper Information

Title: 

EFFECTS OF PENTOXIFYLLINE ON NEUROPATHIC PAIN RESPONSE IN CHRONIC CONSTRICTION INJURY MODEL IN RAT

Type: POSTER
Author(s): SHIRVANIAN M.J.*,SAFAKHAH H.A.,VAKILI ABEDIN,RASHIDIPOUR A.
 
 *DEPARTMENT AND RESEARCH CENTER OF PHYSIOLOGY, SCHOOL OF MEDICINE, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Previous studies indicated that pentoxifylline (PTX) diminished formalininduced pain behavior, naturopathic pain (nerve transaction model) in rats and post-operative pain in humans. Despite, effect of chronic administration of PTX on neuropathic pain in chronic constriction injury (CCI) model is not completely clear. Neuropathic pain was induced by sciatic nerve ligation using CCI model in rats. PTX (30, 60 mg/kg, i.p.) and or saline (vehicle) administered at 30 min before CCI and daily for 14 days. Thermal hyperalgesia was tested for paw withdrawal latency (plantar test) to thermal stimuli on day 3, 7, 11 and 14 after CCI in rats. Administration of PTX at doses 30 or 60 mg/kg significantly reduced thermal hyperalgesia measured on days 7, 11 and 14 after CCI in comparison with control group (P<0.001). Finding of this study indicated that chronic administration of PTX attenuated heat hyperalgesia in CCI rat models of neuropathic pain.

 
Keyword(s): PENTOXIFYLLINE, NEUROPATHIC PAIN, CCI, THERMAL HYPERALGESIA, RAT
 
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