Paper Information

Title: 

INTERACTION OF HISTAMINE AND IT’S H1 AND H2 ANTAGONISTS IN THE NUCLEUS ACCUMBENS OF RATS IN THE ELEVATED PLUS-MAZE TEST OF ANXIETY

Type: POSTER
Author(s): TAHERI SABA*,ORYAN SHAHRBANOU,ZARINDAST M.R.,SARAHROUDI SH.
 
 *DEPARTMENT OF BIOLOGY, SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Nucleus accumbens receives histaminergic neurons from tuberomammillary nuclei. There are some evidences indicating that central histamine system is involved in some behavioral processes, including anxiety. The aim of the present study was to assess whether the histaminergic system of nucleus accumbens is involved in the anxiexty-like behaviors in the elevated plus maze. Intra-accumbal administration of histamine (0.01, 0.1 and 1μg/rat) increased %OAT and %OAE but not locomotor activity, indicating an anxiolytic response. Intra-accumbal microinjection of pyrilamine (H1 receptor antagonist; at the doses of 0.01 and 0.1μg/rat) or ranitidine (H2 receptor antagonist; at the doses of 0.001, 0.01 and 0.1μg/rat) also increased %OAT and %OAE but not locomotor activity. Intraaccumbal administration of pyrilamine (1μg/rat) or ranitidine (1μg/rat) reversed the effects of Intra–accumbal injection of histamine (0.01, 0.1 and 1μg/rat) and showed an anxietic response.

 
Keyword(s): HISTAMINE, PYRILAMINE, RANITIDINE, ANXIETY, RAT
 
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