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Paper Information

Title: 

LOCALIZATION OF THE BRAIN STEM ANTINOCICEPTIVE EFFECTS OF OREXIN-A ON FORMALIN INDUCED NOCICEPTIVE BEHAVIORS

Type: POSTER
Author(s): AZHDARI ZARMEHRI H.*,SEMNANIAN S.,FATH ELAHI Y.,AZIZI HOSSEIN
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Despite the intense interest in the role of orexin in the antinociception and dense projection to brain stem, the site of action of orexin within this region yet to be thoroughly investigated. This study was done in male Spruge Dawley rats on formalin test (50μl of 2% injected into the ventral surface of right hind paw). The formalin induced behaviors in the rat, a model of post injury central sensitization, was studied after microinjections of orexin-A (ORXA, 1-10nmol, 0.5μl) into several brain regions such as periaqueductal grey matter (PAG), nucleus raphe magnus (NRM) and reticularis gigantocellularis (Gi) nucleus that are involved in control of nociceptive behaviors. In this study, ORXA microinjection in the NRM vigorously inhibited formalin induced nociceptive behaviors. ORXA microinjection in the NRM, significantly decreased formalin induced behaviors, in the PAG had moderate effect and in the Gi had not any effect. We used morphine (0.5μg, 0.5μl), as a positive and vehicle as negative control. Probably, orexinergic system from hypothalamus to NRM has a potential role in the modulation of nociceptive transmission in formalin test.

 
Keyword(s): OREXIN-A, PARAGIGANTOCELLULARIS LATERALIS, NUCLEUS RAPHE MAGNUS, OREXIN-1 RECEPTOR, FORMALIN TEST
 
 
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