Paper Information

Title: 

INJECTION OF BACLOFEN AND CGP35348 IN AC NUCLEUS OF AMYGDALA AND AGGRESSION

Type: POSTER
Author(s): TAHERIANFARD M.*,ABD ELAHI Z.,MOLAZADEH JAVAD
 
 *DEPT OF PHYSIOLOGY, SCHOOLOF VET MED, SHIRAZ UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

GABAergic system has important role in aggression. So, the aim of present investigation is to study the effect of injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) in ac nucleus of amygdale on aggression behavior. Thirty six adult male rat weighted 200-240 were kept under controlled temperature (21-24). Water and food was ad libitum. Cannulas were implanted into ac and am nucleus of amygdale using stereotaxic method. Aggression were induced by 2 Ma current every 3 seconds for 5 minutes, it means in every session animal were received 100 electrical shock. After electrical shock, another rat was placed in electroshock chamber. The behaviors that observed in these experiments are as follows: a) approach movements toward the other rat b) aggressive posture- the aggressive animal orients. c) Aggressive groom- nibbling on grooming fur of the other rat. d) Threat head movement toward the other rat. e) Attack rapid movement toward the other rat. G) Offensive upright aggressive- rat stands on hind legs, head oriented toward the other rat. H) Offensive side way- aggressive rat approach other rat broadsides. I) chase –chasing the other rat. J) bite- biting the other rat. Data were analyzed by one and two ways of ANOVA. Significant level was P<0.05. Our data showed that Baclofen injection in ac nucleus of amygdale lead to significantly (P<0.05) decrease in aggressive behavior. CGP35348 injection in ac nucleus of amygdale induced increase in aggressive behavior significantly (P<0.05). Our results indicated that GABA system in ac nucleus of amygdale modulates aggressive behavior due to GABAB receptors.

 
Keyword(s): AGGRESSION, AMYGDALE, CGP35348, BACLOFEN AND RAT
 
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