Paper Information

Title: 

EFFECTS OF FORCED SWIM STRESS ON PTZ INDUCED SEIZURE IN RAT

Type: POSTER
Author(s): TAKHTI T.,FEREYDOUNI MASOUD*,MOGHIMI ALI,BEHNAM RASOULI MORTEZA
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCES, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Relationship between stress and epilepsy has a long history and there are different discussions about effects of stress on epilepsy. For clarification of this relationship, we studied influences of chronic stress on epileptic convulsions induced by chronic and acute PTZ. We used adult male Wistar rats (200-250g) with second control groups for this study. First group with one session of injection (45 mg/Kg PTZ i.p.) and last group with 3 session of injections (25 mg/Kg PTZ, 15 min) used for this study. For stress induction, swimming test was used 30 min before PTZ injection for both groups. Injection of PTZ was done for the first group 24 h after swim stress and for another group 24 h after 3 sessions of stress (24 h between each one). After these injections we examined epileptic behaviors. Statistical ANOVA and Tukey test showed that there are reduced epileptic behaviors in contrast to control groups. This behavior for this group (injection 45 mg/Kg PTZ) with 30 min swimming stress was after 5 min (P<0.05), for group (24 hr stress before injection) on 10-15 min (P<0.01) and for another group (injection PTZ 24 hr after 3 session) on 5 min (P<0.05) and 10-15 (P<0.01) was shown. We showed that 30 min before swim stress on 25 mg/Kg with 3 session prescription injection, increased epilepsy on 10- 15 (P<0.01) and 25-30 min (P<0.05). 24 hr PTZ prescription after 3 session stress on 15-20 min (P<0.05) and 20-25 (P<0.01) reduced intense of epilepsy. Stress caused both exciting and inhibitory effects. It is suggested that when a factor such as PTZ (25 mg/Kg) fortifies seizure effects, stress suppresses seizure effects. PTZ prescription (25 mg/Kg) in contrast to 45 mg/Kg has little influence on nervous system for revealing epilepsy. Thus exciting part of stress adds to functions of PTZ and strengths its effects. Chronic stress activates compensation systems that regulate increased exiting nervous systems cells in area that connected to revealing seizure. Thus, 24 hr after third stress, reduced effect of PTZ function is shown.

 
Keyword(s): SWIM STRESS, PTZ, EPILEPSY, SEIZURE
 
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