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Paper Information

Title: 

ABAPENTIN EFFECT AND INTERACTION ON ANTINOCICEPTIVE EFFECT OF MORPHINE ON VISCERAL PAIN IN MICE

Type: POSTER
Author(s): SHAMSI MEYMANDI M.*,SEPEHRI GH.R.
 
 *DEPARTMENT OF PHARMACOLOGY, IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Visceral pain is one of the most common forms of pain which seek medical attention and require new drugs investigation. In this study the effect of Gabapentin in visceral pain was investigated and compared with morphine. Visceral pain was measured based on the number of abdominal contractions produced after intraperitoneal injection of acetic acid (0.6%) in mice. Animals received saline or Gabapentin (10, 50 and 100 mg/kg) or morphine (0.25, 0.5 and 1 mg/ kg) 40 minutes before acetic acid. Data were expressed as Mean± SE and P<0.05 was considered significant. Gabapentin and morphine reduced writhing in a dose-dependent manner. The number of writhes decreased significantly by Gabapentin (50 and 100 mg/kg) and morphine (0.5, 1 mg/kg). In visceral pain Gabapentin has comparable efficacy of morphine. This may be clinically relevant in a safe management of visceral pain considering its low side effect.

 
Keyword(s): GABAPENTIN, MORPHINE, VISCERAL PAIN, MOUSE
 
 
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