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Paper Information

Title: 

A SIMPLE MODEL OF KINDLING IN PREGNANT RAT

Type: POSTER
Author(s): TOUHIDI ATEFEH*,POURMOTABED ALI,NEDAEI S.E.,MORADIAN S.,CHERAGHIAN M.
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Little attention has been paid to postnatal physiological alterations induced by maternal epilepsy. Kindling is a model of chronic epilepsy. Previous studies on maternal epilepsy model are based on intracortical injection of penicillin with steriotaxic device during pregnancy. The aim of the current study is to introduce a simple model of kindling in pregnant rats. Pregnant rats were injected intraperitoneally with varying doses of Pentylenetetrazol (PTZ) in 3 experimental groups. Group 1 received PTZ (35 or 40 or 45 mg/kg) every other day during the pregnancy. Animals in group 2 received PTZ (40 or 50 or 70 mg/kg) once a day from day 8 to 18 of pregnancy. Rats in group 3 received PTZ (25 or 35 mg/kg) every 15 min (2 or 3 times) on the 13th day of pregnancy until seizure occurred. After each PTZ injection, rats were observed for 30 min, and seizure severity was evaluated using five-score scale. Only animals in group 3 which received PTZ (25 mg/kg) showed generalized tonic-clonic type seizures. Normal deliveries on the 21st or 22nd gestational day were observed. Neonates were also normal and mature. Injection of PTZ (25 mg/kg, i.p.) every 15 min on the 13th day of pregnancy is so effective to produce a simple and safe model of kindling in rats.

 
Keyword(s): KINDLING, RAT, PREGNANCY, PTZ
 
 
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