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Paper Information

Title: 

MATERNAL PSYCHOLOGICAL STRESS REDUCES MORPHINE- INDUCED LOCOMOTION TOLERANCE IN F2 GENERATION IN MICE

Type: POSTER
Author(s): ROSTAMKHANI F.*,ERFANI MARJAN,BANANAJ MARYAM,SAHRAEI HEDAYAT
 
 *DEPARTMENT OF PHYSIOLOGY AND BIOPHYSICS, SCHOOL OF MEDICINE AND APPLIED NEUROSCIENCE RESEARCH CENTER, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In the present study, we studied the effects of maternal psychological stress on the effectiveness of morphine in induction of locomotion tolerance by open field method in F2 generation. 30 pregnant female MNARI mice (25±2 g) were placed in a communication box manufactured by Borj-E-Sanat-ETehran Co., in which can induced psychological stress. Animals were irregularly experienced a trial (each trial = 60 min/day) of stress for 15 days. Our results indicated that mean activity in control animals was 39±3, which was significantly different from experiment group (58±4). The effect of morphine was enhanced by dextrometorphane (NMDA receptor antagonist) and reduced by sulpiride (dopamine D2 receptor antagonist). It could be concluded from these experiments that morphine effectiveness is reduced in animals with stress history and NMDA and D2 dopamine receptors may be involved in this regard.

 
Keyword(s): STRESS, LOCOMOTION ACTIVITY, MORPHINE, MOUSE
 
 
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