Paper Information

Title: 

EVALUATION OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRACT OF VALERIANA OFFICINALIS IN RAT BY FORMALIN TEST

Type: POSTER
Author(s): ARZI ARDESHIR*,SARKAKI A.R.,AGHEL N.,NAZARI Z.,HENDIJANIZADEH SH.
 
 *AHVAZ MEDICAL SCIENCES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The side effects of synthetic analgesic drugs in the clinical practice have turned the attention of researchers to focusing on development of herbal medicines as more appropriate analgesic agents. The purpose of study was evaluation of analgesic effects of the hydroalcoholic extract of Valeriana officinalis in comparison to analgesic agents such as morphine and aspirin. For preparing the hydroalcoholic extract of Valeriana officinalis the ethanol 70% and the maceration technique were used. The prepared extract was concentrated by the evaporation in vacuum device and then it was dried in low temperature. This study was conducted on male Wistar rats weighting 150-180g. Animals were divided into seven groups with 6 in each and received 200, 400, 600 and 800 mg/kg/5ml intraperitoneal injection of the hydroalcoholic extract of Valeriana officinalis. The rats in the “negative control” received normal saline (5ml/kg) and the “positive control” group received intraperitoneal 2.5 mg/kg/5ml morphine, 300 mg/kg /5ml aspirin. The analgesic effects of different doses of the extract were investigated via formalin test. The results revealed that the prepared extract in the all injected doses, had analgesic effects in whole studied periods and in the all times showed significant differences (p<0.05) in comparison to the “negative control”. The highest effect of analgesia was seen by dose of 600 mg/kg. Considering the results, we found that the dose of 600 mg/kg/5ml of the extract are comparable to dose of 2.5 mg/kg/ 5ml of morphine and 300 mg/kg/5ml of aspirin. Results showed that the prepared extract, same as morphine, inhibits both of the pain phases. In addition to determine the role of opioid receptor on analgesic effect of Valeriana officinalis, one group of animals was treated with naloxane (1 mg/kg/5ml,ip), with suitable dose of extract (600 mg/kg/5ml,ip). Naloxane can inhibit analgesic effect of extract. Therefore it is possible that extract exerts its effect through opioid receptor.

 
Keyword(s): VALERIANA OFFICINALIS, PAIN, FORMALIN TEST, RAT
 
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