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Paper Information

Title: 

DIFFERENT EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITION ON MORPHINE INDUCED ANTINOCICEPTION IN MALE AND FEMALE RATS

Type: POSTER
Author(s): TAYARANI Z.*,HOSSEINI MAHMOUD,HAJZADEH M.A.R.,SALEHABADI S.,TEHRANIPOUR M.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, AZAD UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In the present study the chronic effect of L- NAME (NO synthase inhibitor) on morphine induced antinociception in male and female rats was investigated. Forty rats were divided into four groups: 1) female 2) female LN 3) male 4) male LN. The animals of groups 2 and 4 received daily injection of L-NAME (10 mg/kg) during 3 weeks. The animals of groups 1 and 3 received 2ml/kg saline instead of L-NAME. Finally, all animals were tested on the hot plate test for evaluating the antinociceptive effects of morphine. There were no significant differences in baseline latencies among all groups. Reaction times after injection of morphine in female LN were higher than female group (p<0.01). However, there was no significant difference between male and male LN groups. Reaction times in female LN group, was significantly higher than male LN group. Reaction time after injection of morphine in male group was higher than female group. It is concluded that sex hormones such as testosterone and estrogen have a role in pain perception and analgesia. On the other hand, NO has a modulatory effects on functions of sex hormones in pain perception and analgesic effects of opioids.

 
Keyword(s): L-NAME, SEX, MORPHINE, PAIN
 
 
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