Paper Information

Title: 

THE EFFECTS OF CIMETIDINE DIFFERENT DOSES IN CONTROL OF POST OPERATIVE PAIN

Type: POSTER
Author(s): MILADI GORJI H.,FOROUZESHFARD M.*,GHORBANI RAHEB,SHAFIEI ANOUSH,YAZDANMEHR M.
 
 *AMIR AL-MOMENIN HOSPITAL, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Pain is the most common complaint of patients and therefore its treatment is the most ancient problem of human being. Opioids have many side effects that have limited morphine administration. Recent studies have shown that cimetidine (CIM) induce analgesia in animals and humans. This study was designed to evaluate of cimetidine analgesic safe dose in control of post operative pain (dose-response study).
Materials & Methods: This study was a double blind clinical trial .120 patients (male & female) after earning satisfaction were divided to three groups: A) CIM (3mg /kg) B) CIM (6mg /kg) C) CIM (8mg /kg) D) MOR (0/1 mg/kg). Drugs were injected (IV) in peak of pain during post operation period. Numeric Rating Pain Scale (RPS) method was used for pain scaling .Pain was measured in 3o min, 60 min and 120 min after the during injection and compared with pain score before injection of drug.
Results: Pain intensity was not significant at before injection, 30, 60 min 120 min after the drug injections among four groups (morphine and CIM groups) ,but it was significantly lower when compared with pain score before injection of drug (P<0.05). Also, there were no significant differences in duration of analgesia among four groups.
Conclusion: The results of this study indicated that the analgesic effect (time and quality) of CIM (each three doses) is compatible with that of morphine. Therefore it is a safe drug in control of post operative pain.

 
Keyword(s): CIMETIDINE, MORPHINE, ANALGESIA, POST OPERATIVE, DOSE
 
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