Paper Information

Title:  ANTINOCICEPTIVE EFFECT OF CINNAMON EXTRACT ON FORMALIN INDUCED PAIN IN RATS
Type: POSTER
Author(s): DASHTI RAHMATABADI M.H.*,VAHIDI MEHRJARDI A.R.,FARZAN F.
 
 *DEPARTMENT OF PHYSIOLOGY, SHAHID SADOUGHI MEDICAL UNIVERSITY, YAZD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Herbal medicine has an old history with a broad application such as pain reliever all over the world. Many researchers have focused on the curative as well as antinociceptive effects of herbal extracts. Cinnamon Zeylanicum haslong been prescribed in traditional medicine for the treatment of inflammatoryrelated diseases such as rheumatisms, bronchitis and muscle pains. However there is little if any scientific research indicating this effect. This experimental study was carried out in Shahid Sadughi Medical School on 25 Wistar Rats (200-300grams) which randomly divided into 5 groups. In this study the analgesic effect of intrapritoneal administration of hydro-alcoholic Cinnamon extract in different doses (50,100,500mg/kg) were assessed using Formalin Test (for chronic pain) during 1hr post Formalin injection. Our result indicates that the cinnamon extract in high dose (500mg/kg) decreased the chronic pain intensity in the second phase of formalin test. This analgesic effect was significant (P<0.001) as compared with sham group, but the lower doses (50 & 100mg/kg) of cinnamon extract did not show any analgesic effect on chronic pain in Formalin Test. Data from this study confirms the analgesic effect of high doses (500mg/kg) of cinnamon extract on chronic pain in Formalin Test which may be due to anti-inflammatory effect of this plant material.

 
Keyword(s): CINNAMON, CHRONIC PAIN, RAT, FORMALIN TEST
 
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