Paper Information

Title: 

EVALUATING THE ANALGESIC EFFECT OF ARTEMISIA SIEBERI BESSER HYDRO-ALCOHOLIC EXTRACT ON NEUROGENIC AND INFLAMMATORY PAIN IN MICE

Type: POSTER
Author(s): MORSHEDI A.*,DASHTI RAHMATABADI M.H.,DEHGHAN HARATI M.,BAGHERINASAB M.A.,SALAMI A.A.S.
 
 *DEPARTMENT OF PHYSIOLOGY, SHAHID SADOUGHI MEDICAL UNIVERSITY, YAZD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Nowadays herbal therapy for pain relief is the matter of considerable propensity. Artemisia Sieberi besser is one of the herbal medication which has been considered as a pain reliever in Iranian traditional medicine, which needs further scientific investigations. In this study, the antinociceptive effect of hydro alcoholic Artemisia Sieberi besser extract (AE) was assessed using formalin test in mice. 42 male mice were divided into 7 groups. Interaperitoneal administration of distilled water to control group, vehicle to negative sham group,1 and 2 mg/kg morphine to positive sham groups and 40, 400, and 4000 mg/kg AE to test groups were performed. 25 μl of 2% formalin was then injected into the plantar surface of animal's hind limb and the animal's pain behavior for one hour was assessed. Mean pain scores in each five minute time block were calculated for each animal and then were statistically analyzed. In acute phase, mean pain score of animals receiving 4000 mg/kg AE was significantly less than control groups p<0.05. The antinociceptive effect of AE was more prominent in the chronic phase so the analgesic effect of 4000 mg/kg AE was significantly more than 2 mg/kg. The data collected from this study indicates the analgesic effect of AE which is more significant in chronic phase and this effect may be due to anti-inflammatory ingredients in AE which needs to be more investigated.

 
Keyword(s): ARTEMISIA SIEBERI BESSER, PAIN, MICE, MORPHINE AND FORMALIN TEST
 
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