Paper Information

Title: 

THE EFFECTS OF 4WEEKS CONTINUOUS TRAINING EXERCISE ON ANXIEOGENIC-LIKE BEHAVIORS INDUCED BY HOMOCYSTEINE IN HIPPOCAMPAL CA1 RATS

Type: POSTER
Author(s): HOSSEINI R.A.S.*,HAJIZADEH MOGHADAM A.,FALAH MOHAMMADI ZIA,AZIZI GHASEM
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF BASIC SCIENCE, UNIVERSITY OF MAZANDARAN, BABOLSAR, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Oxidative stress has been proposed as a possible mechanism underlying many neurodegenerative diseases associated with hyperhomocysteinemia. The effect of homocysteine (HCY) on lipid peroxidation, a current mechanism of oxidative neurotoxicity, was investigated in rat brain. The hippocampal formation plays important role in anxiety related behaviours. Regarding physical exercise as a major protective factor against hippocampal degradation and the pathogenesis of several neuropsychiatric disorders, including anxiety and depression, in the present study we investigated the effects of 4 weeks continuous training exercise onanxiety-like behaviors in homocysteine-induced neurotoxicity in dorsal hippocampus of rat on. Animals were bilaterally implanted with the cannula into the hippocampal CA1 region. Rats in Group A and B received vehicle of Hcy and 0.2?g/rat Hcy intra-CA1 respectively. Rats in Group C as the control and nonrunning group received 0.2?g/rat Hcy intra-CA1 and remained relatively inactive for 4 weeks and finally, rats in Group D 0.2?g/rat Hcy intra-CA1 and scheduled to run in the treadmill for 5 days a week for the whole 4 weeks. Anxiety-like Behaviors were examined with elevated plus-maze. After statistical analysis (P<0.05), it showed that effects of 4 weeks continuous training increased %OAT and %OAE but not locomotor activity. Our Results indicated that 4 weeks continuous training exercise may improve anxieogenic related behaviors induced with Hcy-neurotoxicity.

 
Keyword(s): EXERCISE, DORSAL HIPPOCAMPUS, HOMOCYSTEINE, ANXIETY
 
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