Paper Information

Title: 

INTRACTION OF ASCORBIC ACID AND DOPAMINE D2 RECEPTOR IN THE NUCLEUS ACCUMBENS SHELL IN RESPONSE TO FEEDING

Type: POSTER
Author(s): BADREH F.*,ABBASNEZHAD M.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF BASIC SCIENCES, SHAHID BAHONAR UNIVERSITY OF KERMAN (SBUK), KERMAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Ascorbic acid (AA) is present in high concentrations with heterogenous distribution in the mammalian brain such as nucleus accumbens shell (AcbSh). In the central nervous system released ascorbic acid can regulate dopamineۥ s effects. Central dopamine receptor has a crucial role in feed intake. The aim of the present study is to evaluate the effects of intra-accumbens administration of ascorbic acid and co-administration of D2 agonist and antagonist on feed intake in adult male NMRI rats. The rats (220-300g) were divided into several groups for intra-accumbens injections: control (intact), sham AA (injected vehicle of ascorbic acid), ascorbic acid (10, 50, 250 μg /rat), sham Br (injected vehicle of bromocriptine), bromocriptine (12.5, 25, 50 μg/rat), sham Su (injected vehicle of sulpiride), sulpiride (8 and 16 μg/rat), AA (50 μg /rat) + Br (50 μg/rat) and AA(50 μg /rat) + Su(16 μg/rat). The intra-accumbens administration of ascorbic acid (10, 50, 250 μg /rat) and D2 agonist bromocriptine (25, 50 μg/rat) decreased food intake. Co-administration AA (50 μg /rat) + Br showed a trend towards an attenuation of the Br effect. Administration D2 antagonist sulpiride (8, 16 μg/rat) increased food intake. Co-administration of AA (50 μg /rat) blocked this effect. These results are incorespondent with current theories of dopaminergic control of feeding behavior, and suggest that ascorbic acid can act within the Acb to decreased feed intake and it has an agonistic effect on feeding regulatory effect of D2 receptor.

 
Keyword(s): ASCORBIC ACID, NUCLEUS ACCUMBENS, FOOD INTAKE, BROMOCRIPTINE
 
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