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Paper Information

Title: 

EVALUATION OF ANTICONVULSANT ACTIVITY OF ASTRAGALUS SP. IN MICE

Type: POSTER
Author(s): KHODAPARAST AFRAMJANI A.*,SAYAH M.,SARDARI SOROUSH
 
 *INSTITUT PASTEUR D IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Epilepsy is one of the most common neurologic disorders. There are about 40% resistance to current antiepileptic drugs. Moreover, acute and chronic toxicity of currently used antiepileptic drugs render treatment difficult. Astragalus sp.ethanolin extract (leguminosae) is evaluted for anticonvulsant activity against experimental seizures. A hydroalcoholic (ethanol 80%) extract was prepared from the plant by percolation. Different doses of the extract were administered to the mice and PTZ-induced clonic seizure occurrence and latency were recorded 30 min thereafter. The extract protected mice against clonic seizures dose-dependently (Ed50= 3g/kg). However at some anticonvulsant doses, the extract showed toxic and lethal effects. Determination of the active anticovulsant constituents of the extract is needed.

 
Keyword(s): ANTICONVULSANT, EPILEPSY, SEIZURE
 
 
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