Paper Information

Title: 

THE EFFECT OF HYPERICUM PERFORATUM L. EXTRACT ON PENTYLENTETRAZOLE-INDUCED CHEMICAL KINDLING IN WISTAR RAT

Type: POSTER
Author(s): VALIAN NEDA*,MOGHIMI A.,HOSSEINZADEH H.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Epilepsy is a common neurological disorder and its treatment is very important. The side effects of synthetic drugs have caused increased tendency of using medicinal herbs. According to traditional opinion of anticonvulsant effect for hypericum perforatum L., the purpose of this study was the examination of the effect of h.perforatum aqeous extract on pentylentetrazole (ptz)- induced kindling in rats. Therefore, 50 adult wistar rats (200-250g) were devided into 5 groups. PTZ was injected intraperitoneally to induce kindling (every 48 hours, for 1 month). Before PTZ injection, in all groups saline (10 ml/kg, negative control), diazepam (4 mg/kg, positive control) and aqueous extract of h.perfoatum (in 3 doses 0.4, 0.7 and 1 g/kg, experimental groups) were administrated orally. After each PTZ injection, convulsive behaviors of rats were recorded for 30 min. The results showed that mean seizure intensity in positive control group decreased significantly in comparison to negative control, but there wasn’t significant difference between experimental and control (negative and positive) groups (p<0.05). For hypericum extract tendency to binding to some receptors such as GABA has been suggested. Furthermore, inhibition of catecholamines reuptake and increase in their synaptic concentration, affects some neuronal disorders. Glutamate NMDA receptors involved in development of kindling process, and their antagonists have protective role in induction of this process. Therefore, finding of this research showed that oral administration of hypericum extract hasno effect on PTZ-induced kindling. Thus the examination of anticonvulsant effects of hypericum on other kinds of convulsions is suggested.

 
Keyword(s): CONVULSION, CHEMICAL KINDLING, PTZ, HYPERICUM PERFORATUM
 
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