Paper Information

Title: 

THE EFFECT OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY OF HYDRO-ALCOHOL EXTRACT OF DOREMA AUCHERI ON FORMALINTEST AND CARRAGEENAN MODEL IN RATS

Type: POSTER
Author(s): NIKNAM MANDANA*,MOKHTARI M.,SHARIATI M.
 
 *DEPARTMENT OF BIOLOGY, KAZEROUN BRANCH , ISLAMIC AZAD UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Considering the importance of extracts of Umbelliferae herbs, the present study aimed to investigate the antinociceptive and anti- inflammatory effects of hydro alcoholic extract of Dorema aucheri.
In this experimental study, the experiments were performed on 80 male wistar rats weighting 190 to 200 grams, which were divided into ten groups, each consisting of 8 rats. To evaluate the antinociceptive effects, the formalin induced pain-test was used and for assessing anti-inflammatory effects, the carrageenan induced hind paw edema model in rats was used. All animals were pre-treated with an oral dose of extracts (100, 200, 400 mg/kg). The control group received no drug and the sham group at only received distilled water. Statistical analysis of the data was performed using ANOVA and t-test where appropriate. Results of this study showed that extracts of Diorama archery can significantly reduce the pain depending on the dose in acute phase (p<0.05). However, in chronic phase , the high dose of the extract could reduce the pain. These results also revealed that the highest dose of extract can reduce paw edema in carrageen-an test. It seems that flavonoids can probably reduce intracellular calcium through inhibiting of NMDA receptors. It also reduces activities of nitric oxide synthase enzyme and calcium dependent phospholipids A2, which results in antinociceptive effects. It may also be concluded that the anti-inflammatory effects of the extracts are through reduction of prostaglandins.

 
Keyword(s): PAIN, INFLAMMATION, DOREMA AUCHERI, RAT
 
Yearly Visit 44   tarjomyar
 
Latest on Blog
Enter SID Blog