Paper Information

Title: 

INTRA-AMYGDALOEID NUCLEUS LIDOCAINE INHIBITS MORPHINE-INDUCED PLACE PREFERENCE IN RATS: DIFFERENCE BETWEEN RIGHT AND LEFT SIDE

Type: POSTER
Author(s): MOHAMMADIAN Z.*,SAHRAEI HEDAYAT,ALI BEYGI H.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF BIOLOGY, TEHRAN NORTH BRANCH, AZAD ISLAMIC UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Amygdaloeid nucleus is considered as the important region for induction of psychological dependence to abused drugs such as morphine and nicotine. The region consists of several different neurons in which releases different neurotransmitters as well. The role of these neurons as well as neurotransmitters is investigated in previous studies in detail. The main aim of this study was to investigation of the functional role of each right and left side as well as both sides of the amygdaloeid nucleus by transient inactivation of the nucleus by lidocaine (2%) on morphine reward properties using place conditioning (CPP) method. Male NMARI rats (250-300 g) seven days after recovery from surgery and cannulation were conditioned to morphine (7.5 mg/kg) in an un-biased designed CPP apparatus. Five min before each morphine injection in conditioning phase, lidocaine (2%) was administers either uni- or bilaterally into the amygdaloeid nucleus (1 μl/rat). Results revealed that lidocaine administration into the left but not right side of the amygdaloeid nucleus reduced morphine CPP significantly. The reduction was potentiated when lidocaine injected in to both sides of the amygdaloeid nucleus. In addition, the number of compartment crossing was reduced when lidocaine injected in both side of amygdaloeid nucleus as well as Right side. At last, Sniffing and rearing increased in the group in which received lidocaine in right side and reduced in the group in which received lidocaine in left side of amygdaloeid nucleus. It is concluded that the right and left side of amygdaloeid nucleus plays different role in morphine-induced activity and reward.

 
Keyword(s): AMYGDALOEID NUCLEUS, LIDOCAINE, MORPHINE, RAT
 
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