Paper Information

Title: 

THE DIFFERENCE OF ANALGESIC EFFECT AND TOLERANCE TO MORPHINE BETWEEN OVARIECTOMIZED AND INTACT FEMALE RATS

Type: POSTER
Author(s): KARAMI REZA*,KHODA BANDEHLOU F.,KHATAMI L.,HOSSEINI MAHMOUD
 
 *DEPT OF PHYSIOLOGY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Estrogens have numerous neurobiological effects on the brain through the nuclear hormone receptor activities, which some of these receptors are involved in pain modulation and conduction. In the present study, the morphine tolerance and its analgesic effects in ovariectomized (OVX) rats was investigated. Fourty female rats were divided into 4 groups: 1-Sham, 2- OVX, 3- Sham-Tol, 4-OVX–Tol. Eight weeks after surgery, morphine tolerance was induced by daily injection of 20mg/kg morphine during 4 consecutive days in animals of groups 3 and 4. Animals of groups 1 and 2 were simultaneously treated with 1ml/kg saline, respectively. Hotplate test was carried out in 5th day as a base record, then the animals received 5mg/kg morphine and antinociceptive effect was evaluated every 10 min. The results showed that reaction times after morphine (5mg/kg) injection was longer than base time in sham and OVX groups, but there was no difference in OVX-Tol and Sham-Tol. However the reaction times after injection of morphine (5mg/kg) in sham group was longer than OVX group, and there was no difference between Sham-Tol and OVX-Tol. The results showed that repeated administration of morphine can lead to tolerance. Removing ovaries decreased analgesic response to morphine; however there were no differences between tolerance in the presence and absence of female gonadal hormones.

 
Keyword(s): RAT, OVARIECTOMY, PAIN, TOLERANCE
 
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