Paper Information

Title: 

EVALUATION OF ANTICONVULSANT EFFECT OF CARAWAY EXTRACT IN MICE

Type: POSTER
Author(s): SHOURAKI A.R.*,EMAM GHOREYSHI MASOUMEH
 
 *DEPARTMENT OF PHARMACOLOGY, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Carum Carvi L. (Caraway) has been indicated for a number of medical conditions in traditional medicine such as convulsion, lactation and gastric disorders. However, there is not yet any report investigating the anticonvulsant effect of caraway. Therefore, the aim of this study was to determine whether the aqueous extract of caraway seeds has an anticonvulsant effect in mice. Anticonvulsant effect of caraway was assessed pentylenetetrazole (PTZ)-induced convulsion model. Male albino mice were received the aqueous extract of caraway (100, 200, 400, 600 or 800 mg/kg; n=7) or water (vehicle; n=7) intraperitoneally 30 minutes before the injection of PTZ (95mg/kg). Diazepam (3mg/kg; n=7) was used as a reference drug. The latency time before the onset of myoclonic, clonic and tonic convulsions, the percentage of animals shown convulsion and the percentage of mortality were recorded. The aqueous extract at dose of 800 mg/kg increased the latency of myoclonic and clonic convulsions significantly. ED50 for protection against PTZ-induced death was 95 mg/kg. The results suggest that caraway has anticonvulsant effect and may have a potential use in seizure.

 
Keyword(s): CARUM CARVI, ANTICONVULSANT EFFECT, PTZ, DIAZEPAM, MICE
 
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