Paper Information

Title: 

EFFECT OF GABAA RECEPTOR ANTAGONIST ON OPIOID–INDUCED ANTINOCICPTION IN THE FORMALIN TEST

Type: POSTER
Author(s): HOSSEINI NASRIN*,SAFARI T.,ABBASNEZHAD MAHDI
 
 *DEPARTMENT OF PHYSIOLOGY, ESFEHAN UNIVERSITY OF MEDICAL SCIENCES, ESFEHAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Opioids have been mainstay of pain treatment for thousands of years, and remain so today. Opioids exert their therapeutic effects by mimicking the action of endogenous opioid peptides at opioid receptors. The midbrain periaqueductal gray (PAG) and adjacent nucleus ceuniformis and their major caudal projection target, the rostral vrntromedial medulla (AVM), are among the CNS sites that contain opioid peptid-immunoreactive terminal field, are sensitive to the antinociceptive action exogenous opioid and have been implicated in pain modulation. The anatomical link between the PAG-cuneiformis region and the RVM provides a potential target for elucidating the role of exogenous opioid, in pain modulation. In this work, the effects morphine and γ-aminobutyric acid A (GABAA) receptor agonist in cuneifurmis nucleus with formalin test were investigated in rats. Morphine (10 μgr/rat), Bicuculline (50, 100ngr/rat) and Morphine in combination with Bicuculline were microinjected into nucleus cuniformis. In order to analyze the data, statistical tests including t- test and ANOVA-one way at the significant level P<0.05 were used. Microinjection of morphine (10μgr/rat) induced an antinociception in the both first and second phases of the formalin test. Bicuculline (50, 100 ng/rat) has produced antinociception in the both first and second phase of the formalin test. Morphine in combination with Bicuculline did not influence the response induced by morphine in the both first and second phases of the formalin test. On the basis of the findings of the study, the antinociception induced by GABAA receptor antagonist may partly be mediated through nucleus cuneiformis opioid receptor mechanisms.

 
Keyword(s): MORPHINE, BICUCULLINE, NUCLEUS CUNEIFORMIS, FORMALIN TEST
 
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