Paper Information

Title: 

EFFECTS OF NEW DERIVATIVES OF PHENCYCLIDINE ON ANXIETY BEHAVIORS IN ADULT MALE WISTAR RATS

Type: POSTER
Author(s): SOULATI JALAL,AHMADI ABAS,SALARI A.A.*
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, ISLAMIC AZAD UNIVERSITY, NORTH TEHRAN BRANCH, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Anxiety is a common disorder that attacks many people in society and is often accompanied by physiological sensations such as tachycardia, chest pain, shortness of breath, insensitivity and etc. Phencyclidine (1-(1- phenylcyclohexyl) piperidine, CAS 956-90-1, PCP, I) and its derivatives have shown many pharmacological and behavioral effects. Different brain sites and receptors are involved in modulate behavioral effects of this families. The purpose of this study is to characterize the putative anxiolytic-like effects of two methyl and methoxy (II, III) hydroxyl derivatives of phencyclidine, using elevated plus maze test of anxiety. Intraperitoneal (IP) administration of PCP and it’s analogues (I, II, III) hydrochloride (1, 2, 5 mg/kg) induced an anxiolyticlike effect, shown by specific increases in the percentage of open arm time (OAT%) and percentage of open arm entries (OAE%).

 
Keyword(s): ANXIETY, METHYL AND METHOXY HYDROXYL, DERIVATIVES OF PHENCYCLIDINE, RAT
 
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