Paper Information

Title:  FINASTERIDE, A 5ALPHA- REDUCTASE ENZYME INHIBITOR, ALONE AND IN COMBINATION WITH A NEUROSTEROID REDUCES RESPONSIVENESS TO NOCICEPTIVE STIMULI IN MALE RAT
Type: POSTER
Author(s): VERDI J.,SHARIF SH.,AHMADIANIN A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Several lines of evidence support an important role for testosterone in pain modulation. Recently, we have recorded that finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine. Meanwhile, the effects of finasteride alone and in combination with a neurosteroid, testosterone, on pain remain undetermined. In the present study, we investigated the effects of finasteride alone (5- 300 mg/kg, i.p.) and combined with testosterone (1 mg/kg, i.p.) in both acute (tail- flick latency test, TFL) and chronic (formalin- test, FT) pain models. We found that finasteride alone (5- 300 mg/kg, i.p. with dosedependent, ED50, 124 mg/kg) produced significant analgesia response in both phases of formalin test. But, finasteride alone did not affect the tail- flick test. In addition, concomitant administration of testosterone with finasteride produced a significant antinociception effect in both acute and chronic pain. The results of this study demonstrated that finasteride not only enhances testosterone antinociceptive effect but also is analgesic itself. According to these results, it seems that there is an interaction between a neurosteroids and a 5alpha-reductase enzyme inhibitor in the pain.

 
Keyword(s): FINASTERIDE, NEUROSTEROID, ANALGESIA, 5ALPHA- REDUCTASE ENZYME, MALE RAT
 
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