Paper Information

Title: 

COMPARISON OF THE EFFECT PROPRANOLOL, CAFFEINE AND DIAZEPAM ON LIDOCACAINE INDUCED CONVULSION IN MICE

Type: POSTER
Author(s): BAKHTIARI ELHAM*,MEHRZADI SAEID,NAJAFZADEH VARZI H.
 
 *SCHOOL OF VETERINARY MEDICINE, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Propranolol has cardiovascular and also central effects. At this study, the effect of propanolol was compared with caffeine and diazpam on convulsion induced by lidocaine in mice. The study was done on 4 groups of mice. Lidocaine was administted at dose 30mg/kg – ip in group 1. Diazpam was injected at dose 2mg/kg-ip 15 min before lidocaine in group 2. Proranolol was injected at dose 5mg/kg-ip 15 min before lidocaine in group 3. Caffeine was injected at dose 10mg/kg+ip15 min before lidocaine in group 4. The initiation, number and duration of convulsion were counted in mice and the mean of these factors was evaluated. In group 1, the convulsion initiated 5 min after lidocaine injection and the mean and the number of convulsions was 3.5 min and 22, respectively. No convulsion was seen with diazpam. The convulsion was seen at two mice of group 3 and 4. Thus, the results of this study show that propranolol and caffeine can reduce lidocaineinduced convulsion.

 
Keyword(s): CONVULSION, LIDOCAINE, DIAZPAM, CAFFEINE, PROPRANOLOL, MICE
 
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