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Paper Information

Title: 

THE EFFECT OF ZATARIA MULTIFLORA BOISS ON β2- ADRENOCEPTORS OF GUINEA PIG TRACHEAL CHAINS

Type: POSTER
Author(s): KAVEH MAHSA*,BOSKABADI M.H.,EFTEKHAR N.,NEMATI ALI
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, ISLAMIC AZAD UNIVERSITY,MASHHAD BRANCH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The relaxant effect of Zataria multiflora Boiss (Labiatae) in ileum and uterus tracheal smooth muscle has been demostrated. Therefore, the effect of aqueousethanolic extract of this plant, on β-adrenoceptors was examined on tracheal chains of guinea pigs. The effects of three concentrations of aqueous-ethanolic extract (0.05, 0.1 and 0.2 mg/mL), 10 nM propranolol, and saline on β-adrenoceptors were tested (n=8). The results showed clear leftward shifts in isoprenaline curves obtained in the presence of all concentration of the extract compared with that of saline. The EC50 (the effective concentration of isoprenaline, causing 50% of maximum response) obtained in the presence of all concentrations of the extract was significantly lower compared to saline (p<0.05 to p<0.001). The maximum responses obtained in the presence of all three concentrations of the extract were not significantly different compared with that of saline. All values of (CR-1 = EC50) obtained in the presence of active substances/EC50, obtained in the presence of saline -1 obtained in the presence of concentrations of extract were negative and there were significant differences in this value between propranolol and those obtained in the presence of extract (p<0.01 for all three cases). The results indicated a relatively potent stimulatory effect of the extract from Zataria multiflora Boiss on ß2-adrenoceptors.

 
Keyword(s): ZATARIA MULTIFLORA BOISS, β-ADRENOCEPTORS, GUINEA PIG
 
 
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