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Paper Information

Title: 

RELAXANT EFFECTS OF ACHILLEA WILHELMSII ON GUINEA-PIG TRACHEAL CHAINS

Type: POSTER
Author(s): EFTEKHAR N.*,BOSKABADI M.H.,KAVEH MAHSA,NEMATI ALI
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, ISLAMIC AZAD UNIVERSITY, MASHHAD BRANCH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Achillea wilhelmsii have been used in folk remedies and its different pharmacological effects including its lowering blood pressure effect was demonstrated. Therefore in the present study, the relaxant effects of the extract of Achillea wilhelmsii on tracheal chains of guinea pigs were examined. The relaxant effects of four cumulative concentrations of the extract (2, 4, 6 and 8 mg/ml) in comparison with saline as negative control and four cumulative concentrations of theophylline (0.2, 0.4, 0.6 and 0.8 mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig induced by10 μM methacholine (n = 11). All concentrations of theophylline and three last concentrations of the extract (4, 6, and 8 mg/ml) showed significant relaxant effects compared to that of saline (p<0.001 for all cases). However, the relaxant effects of three lower concentrations of the extract (2, 4, and 6 mg/ml) were significantly less than those of theophylline (p<0.01 to p<0.001). There were significant positive correlations between the relaxant effects and concentrations for both theophylline and the extract (p<0.001 for both cases). These results showed a relatively potent relaxant effect for the extract of Achillea wilhelmsii on tracheal chains of guinea pigs.

 
Keyword(s): ACHILLEA WILHELMSII, RELAXANT EFFECT, TRACHEAL CHAINS, GUINEA PIG
 
 
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