Paper Information

Title: 

POSSIBLE MECHANISM (S) FOR THE RELAXANT EFFECT OF CROCUS SATIVUS (SAFFRON) ON GUINEA PIG TRACHEAL CHAINS AND ITS POSSIBLE MECHANISM (S)

Type: POSTER
Author(s): BOSKABADI M.H.,ASLANI M.R.,HOSSEINI -*
 
 *DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGICAL RESEARCH CENTER OF MEDICAL PLANTS, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Therapeutic effect of Crocus sativus on respiratory diseases is indicated in Iranian ancient Medical books. Therefore, the possible mechanisms for the relaxant effects of Crocus sativus on tracheal chains of guinea pigs were examined. The relaxant effects of 4 cumulative concentrations of aqueousethanolic extract in comparison with saline as negative control and 4 cumulative concentrations of theophylline as positive control were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60mM KCl in two different conditions including: non-incubated tissues (group 1) and incubated tissues with 1μM propranolol 1μM chlorpheniramine and 1Μm atropine (group 2), (for each group, n=6). In groups 1 all concentrations of theophilline, extract showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). However, in group 2 the extracts of Crocus sativus showed a weak relaxant effect (p<0.05 only for highest concentration). The relaxant effect of most concentrations of extract in group 1 were significantly higher than those of group 2 (p<0.05 to p<0.001). These results suggested that the relaxant effect of this plant could be due to b-adrenoceptors stimulatory, muscarinic and/or histamine (H1) receptor inhibitory effect. A possible inhibitory effect of aqueous-ethanolic extract on calcium channels is also postulated.

 
Keyword(s): CROCUS SATIVUS, RESPIRATORY DISEASES, RELAXANT EFFECT, GUINEA PIG
 
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