Paper Information

Title: 

EFFECT OF AQUEOUS EXTRACT OF ALTHAEA ROOT ON TRACHEAL SMOOTH MUSCLE OF RAT

Type: POSTER
Author(s): NOUR ALDINI M.*,MOUSAVI LORDJANI M.
 
 *DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, SCHOOL OF MEDICINE, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Excitation and contraction of the smooth muscles in the airways lead to the constriction which causes abnormal airflow .Since the spasm of the air ways is a very common syndrome in human communities, the study of factors affecting contractile activity of the tracheal muscles can be helpful in the control of pulmonary obstructive disease, so this study was designed to determine the effect of aqueous extract of Althaea root on tracheal smooth muscle of rat. For this purpose, the trachea (N:30, 5mm) of a healthy and male rat (N=15, Sprague Dawley, 200-250 gr) was dissected and its contractions were recorded isotonically under one gram tension in an organ bath containing kerebs-hancelit solution in 6 groups (N=5). T-test and one and two-way ANOVA were used to compare the results. Epinephrine (5μm) alone and Extract cumulative concentrations (0.2, 0.6, 2.6, 6.6, 14.6 μg/ml) reduced the tracheal smooth muscle contractions induced by KCl (60 mM) dose-dependently (ANOVA, P<0.001). The antispasmodic effect of extract (8 μM) was not reduced in the tissue pretreated with propranolol (1μM) but it reduced the antispasmodic effect of Epinephrine (5μm) (ANOVA, P<0.001). It is concluded that aqueous extract of Althaea root inhibited the tracheal smooth muscle of rat contractions dose dependently. It seems that β-adrenoceptors are not involved in this effect.

 
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