Paper Information

Title: 

THE EFFECTS OF PSYCHOTROPIC DRUGS ON NGF PROTEIN LEVELS IN THE RAT BRAIN

Type: POSTER
Author(s): HASANZADEH P.*,HASANZADEH ANA
 
 *DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, AJA UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Psychotropic drugs exert their effects, in part, through increasing neurotrophin levels in the brain. The present study was designed to evaluate the effects of diverse psychotropic drugs on NGF protein levels in five brain regions. Adult male Sprague-Dawley rats received acute or chronic (21 days) injections of desipramine, phenelzine, fluoxetine, chlordiazepoxide (10 mg/kg, each), haloperidol (1 mg/kg), and clozapine (20 mg/kg). 24 hr after the last injection, NGF protein level was quantified in the dissected brain regions using ELISA kit. Acute administration of the drugs did not affect NGF protein levels in the brain. Chronic administration of desipramine, phenelzine, fluoxetine, haloperidol, and clozapine led to the enhancement of NGF in the frontal cortex. Desipramine, fluoxetine, phenelzine and clozapine enhanced NGF in the hippocampus. In the olfactory bulb, desipramine and fluoxetine increased NGF, whereas, phenelzine and haloperidol reduced it. NGF level was not affected by any medication in the amygdala and brain stem. Chronic administration of chlordiazepoxide did not affect NGF proteinin the brain. In conclusion, Psychotropic drugs, based on their therapeutic properties, exert dissimilar effects on NGF protein levels in the brain. This might be related to their effects on the cognitive function.

 
Keyword(s): NERVE GROWTH FACTOR, PSYCHOTROPIC DRUGS, BRAIN, RAT
 
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