Paper Information

Title: 

ROLE OF PERIPHERAL BLOOD DERIVED FIBROCYTE IN SKIN FIBROSIS IN A MURINE MODELOF SCLERODERM

Type: POSTER
Author(s): KATEBI M.*,SOLEYMANI MANSOUREH,SOLEYMANIASL S.,MAHDIZADEH M.,ABBASI MOGHADAM M.A.
 
 *
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Peripheral blood fibrocytes are a newly identified circulating leukocyte subpopulation that migrates into injured tissue where it may display fibroblast-like properties and participate in wound healing and fibrosis of skin and other organs. Fibrocytes produce matrix proteins such as vimentin, collagens I and III, and also express hemopoietic stem cell Ag CD34. Coexpression of Type I collagen and CD34, a phenotype unique to fibrocytes. The aim of this study was to study the recruitment of fibrocytes to the dermis in the bleomycin-induced model of dermal fibrosis. Sections of skin from normal mice and bleomycin-treated wild type C57BL/6mice were stained for procollagen a2 Type I and CD34 and the double stained cells, fibrocytes, were counted in the tissue sections. There were more fibrocytes in the dermis of bleomycin-treated mice than normal mice and. These results suggest that fibrocytes may play a central role in the pathogenesis of fibrosing diseases of the skin.

 
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