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Paper Information

Title: 

STATINS INCREASE NEUROGENESIS IN DENTATE GYRUS OF RATS WITH ALZHEIMER’S DISEASE

Type: POSTER
Author(s): ALIKHANI N.*,YAGHMAEI PARICHEHR,PARIVAR KAZEM
 
 *DEPARTMENT OF BIOLOGY, SCIENCE AND RESEARCH BRANCH, AZAD ISLAMIC UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Alzheimer's disease (AD) is a brain disorder. Just like the rest of our body, our brain changes as we get old. However, serious memory loss, confusion and other major changes are not normal parts of aging. In this study, we examined the effect of statins (simvastatin and atorvastatin) on neurogenesis in male Wistar rats inflicted with AD by ibotenic acid. Experiment 1: male Wistar rats weighing 250-300g were treated with atorvastatin 1 day after injection of ibotenic acid and daily thereafter for 14 days (0.01% Statin in saline). Experiment 2: male Wistar rats were treated with statins for 35 days. At the end of the experiment, animals were decapitated under ether anesthesia and brains were remowed for histological assessment and results compared to control group. Microscopic studies of brain sections from statin-treated animals showed increased neurogenesis in Dentate Gyrus compared to control group. These results suggest that statins may be candidates for treatment of AD and amelioration of memory function.

 
Keyword(s): ALZHEIMER’S DISEASE, RAT, NEUROGENESIS, DENTATE GYRUS
 
 
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