Paper Information

Title: 

TROPISETRON PROTECTS AGAINST THROMBOEMBOLIC STROKE IN RAT

Type: POSTER
Author(s): BARZEGAR FALAH ANITA*,MOHAMMADI SANAZ,RAHIMIAN R.,DANESHMAND A.,FAKHFOURI G.,EJTEMAEIMEHR SH.,DEHPOUR A.R.
 
 *FACULTY OF PHARMACY, AZAD ISLAMIC UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Ischemic stroke frequently results from occlusion of cerebral vessels by a thrombus generation, leading very quickly to irreversible neuronal injury. In the present study, we examined the neuroprotective effects of tropisetron, a 5-HT3 receptor antagonist with recently shown anti-inflammatory properties, in a thromboembolic stroke model in rats. 40 male rats were divided into sham, control, tropisetron, phenylbiguanide (a 5-HT3 receptor agonist), and tropisetron + phenylbiguanide groups. All treatments were administered 1h prior to experimental stroke induction. Thromboembolic stroke was rendered according to Shuaib et al. by injection of pre-formed clots into the middle cerebral artery (MCA). Neurological deficits were assessed at 1 and 24 h after the MCA embolization using a modified Bederson’s scoring system. The infarction was evaluated by staining brain slices with 2,3,5-triphenyltetrazolium chloride (TTC) at 24 h following embolic stroke. Tropisetron significantly improved neurological scores after 24h of stroke induction associated with a diminished infarct size in histopathologic evaluation. Phenylbiguanide, however, failed to reverse these positive effects. Tropisetron exerts beneficial properties in experimental thromboembolic stroke independent of its action on 5-HT3 receptor.

 
Keyword(s): TROPISETRON, STROKE, MCA
 
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