Paper Information

Title: 

LITHIUM AMELIORATES ISCHEMIA/REPERFUSION-INDUCED SCIATIC NERVE DAMAGE IN RAT

Type: POSTER
Author(s): MOHAMMADI SANAZ*,BARZEGAR FALAH ANITA,RAHIMIAN R.,EJTEMAEIMEHR SH.,FAKHFOURI G.,DEHPOUR A.R.
 
 *FACULTY OF PHARMACY, AZAD ISLAMIC UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Lithium has been extensively used as a long-term mood stabilizer for the treatment of manic/depressive disorder. Recent evidence suggests lithium exerts neuroprotective effects in experimental and clinical conditions such as MS, ALS and brain ischemia. Regarding the beneficial action of lithium in ischemia/reperfusion (I/R) damage, we investigated probable effects of lithium on I/R injury of the sciatic nerve. Eighty rats were divided into 10 groups (n =8). Treatment groups received 20 mg/kg lithium intraperitoneally 1 h before induction of ischemia by clamping the right common iliac and femoral arteries for 3 h. After certain time intervals of reperfusion (0 h, 3 h, 1, 4, and 7 days), the function of the hind limb was investigated using behavioral scores based on gait, grasp, paw position, and pinch sensitivity. The sciatic nerve was removed for light microscopy studies and graded for ischemic fiber degeneration (IFD) and edema. Behavioral scores were improved in the lithium groups on the 1st, 4th and 7th days of reperfusion (p<0.05). Significant differences in edema were seen between the lithium and control groups on days 4 and 7. IFD significantly decreased in the lithium group at 7 days of reperfusion. These results indicate that lithium possesses neuroprotective properties in the rat model of sciatic nerve damage.

 
Keyword(s): ISCHEMIA, REPERFUSION, SCIATIC NERVE, IFD, LITHIUM
 
Yearly Visit 18   tarjomyar
 
Latest on Blog
Enter SID Blog