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Paper Information

Title: 

THE EFFECT OF SUBCUTANEOUS INJECTION OF CEREBRAL SPINAL FLUID ON ALPHA MOTONEURON DEGENERATION AFTER SCIATIC NERVE INJURY IN RATS

Type: POSTER
Author(s): MOSTAFAEI MARYAM*,TEHRANIPOUR M.,BAHARARA J.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, ISLAMIC AZAD UNIVERSITY, MASHHAD BRANCH, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

One problem to maintain PNS damages is reverse of these damages to neuron cell body that their axon was destroyed. This effect retrograde to reach neuron alpha cell body and induce central degeneration in the spinal cord. CSF consists of valuable components for protection of nervous systems. In this study, Eigheen adult male wistar rats divided in 3 groups (control, compression, com+CSF injection). In compression and experimental right sciatic nerve were highly compressed and 10 μl CSF was injected in experimental group each three days. After 4 weeks post –operative that lumbar segments of spinal cord were sampled , processed , sectioned serially and stained with toluidine blue (PH=4.65). By using sterological quantitative technique the member of alpha motoneurons were counted and compared with each other. Statistical analyses showed a remarkable increase (p <0.05) in experimental groups.
The results indicated that CSF has neuroprotective effects on nervous system and inhibit the degeneration of cell body after sciatic nerve injury.

 
Keyword(s): DEGENERATION, CSF, SCIATIC
 
 
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