Paper Information

Title: 

NEUROPROTECTIVE EFFECTS OF CURCUMA LONGA EXTRACT ON NEURODEGENERATION AFTER SCIATIC NERVE INJURY IN RAT

Type: POSTER
Author(s): JAVAHERIFARD REYHANEH*,TEHRANIPOUR M.,KHAYATZADEH J.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, AZAD ISLAMIC UNIVERSITY, MASHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

There is ample evidence that axonal processes of peripheral and/or central neurons may be degenerated after nerve injuries. Wallerian degeneration and chromatolysis are the most conspicuous phenomena that occur in response to injuries. In this research, the effects of Curcuma longa total extract was investigated spinal motor neuron degeneration following sciatic nerve compression. Thirty adult male Wistar rats, underwent right sciatic nerve compression for 60s and were assigned to experimental groups A to C (n=6). In addition, 2 groups were assigned as comperssion and control (n=6). After 4 weeks, the lumbar segment of spinal cord was sampled, processed, sectioned serially and stained with toluidine blue (pH 4.65). Using stereological quantitative technique (physical dissector), the number of alpha motor neurons in the right and left ventral horns of spinal cord were counted and compared with each other. Statistical analysis showed a remarkable reduction in the number of alpha motor neurons in all treatment groups compared to compression group (p<0.05). This increase may be due to antioxidant effects of C. longa extract that inhibits the activated apoptotic pathways.

 
Keyword(s): NERVE INJURY, CURCUMA LONGA, ALPHA MOTOR NEURON
 
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