Paper Information

Title: 

NEUROPROTECTIVE EFFECTS OF THE POLYPHENOLIC ANTIOXIDANT AGENT, CURCUMIN, AGAINST HOMOCYSTEINE-INDUCED COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS IN RAT

Type: PAPER
Author(s): ATAEI AMIN*,SABET KASAEI M.,HAGHPARAST ABAS
 
 *NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Aging is a major risk factor for neurodegenerative diseases and oxidative stress is involved in the pathophysiology of these diseases. In this study, we investigated the possible antioxidant and neuroprotective properties of the polyphenolic antioxidant compound curcumin against homocysteine (Hcy) neurotoxicity. Curcumin (5 and 50mg/kg) was injected intraperitoneally once daily for a period of 10 days beginning 5 days prior to Hcy (0.2 μmol/μl) intrahippocampal injection in rats. Biochemical and behavioral studies including passive avoidance learning and locomotor activity tests were carriedout 24 h after the last curcumin injection. Results indicated that Hcy could induce lipid peroxidation and increase MDA and SOA levels in rats' hippocampi. Additionally, Hcy impaired memory retention in passive avoidance learning test. However, curcumin treatment decreased MDA and SOA levels significantly and also improved learning and memory in rats. Histopathological analysis also revealed that Hcy decreased hippocampus cells, while curcumin inhibited this toxic effect. These results suggest that Hcy may induce lipid peroxidation and neurodegeneration in rats' hippocampi and that polyphenol treatment (curcumin) has the ability to improve learning and memory deficits by protecting the nervous system against Hcy toxicity.

 
Keyword(s): HIPPOCAMPUS, CURCUMIN, HOMOCYSTEINE, LIPID PEROXIDATION, OXIDATIVE STRESS, RAT
 
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