Paper Information

Title: 

TIME-DEPENDENT EFFECTS OF PTX ON POST-ISCHEMIC BRAIN EDEMA IN A TEMPORARY MODEL OF FOCAL CEREBRAL

Type: POSTER
Author(s): MOJARAD S.*,VAKILI ABEDIN
 
 *LABORATORY OF CEREBROVASCULAR RESEARCH, DEPARTMENT AND RESEARCH CENTER OF PHYSIOLOGY, FACULTY OF MEDICINE, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Our recent study has demonstrated anti-edematous effect of Pentoxifylline (PTX) on focal ischemic brain injury, but its time-dependent therapeutic effects are not clear. Under chloral hydrate anesthesia, transient focal cerebral ischemia was induced in 47 male rats by 60 min of middle cerebral artery occlusion (MCAO), followed by 23 h of reperfusion. Saline or PTX (60 mg/kg, ip) was given at the beginning or at 1 or 3 and/or 6h after induction of ischemia. Twenty-hour post-ischemia percentage of brain water content (edema) was determined using the dry-wet method. Administration of PTX at the beginning or 1 or 3 and/or 6h of MCAO, significantly reduced cerebral edema (P<0.001). These findings showed that PTX reduced post-ischemic brain edema with a 6-h therapeutic time window in transient focal stroke.

 
Keyword(s): PENTOXIFYLLINE, TRANSIENT FOCAL CEREBRAL ISCHEMIC, BRAIN EDEMA, RAT
 
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