Paper Information

Title: 

NEUROPROTECTION BY 3 - (METHYLTHIO) – 5 , 6 – DI - (4 – METHOXYPHENYL) – 1 , 2 , 4 - TRIAZINE AGAINST OXIDATIVE-INDUCED CELL DEATH: INVOLVEMENT OF TRANSCRIPTION FACTORS NRF2 AND NF-KB

Type: POSTER
Author(s): KHORAMIAN TOUSI S.,ANSARI NILOUFAR,AMINI MOHSEN,KHODAGHOLI F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Increased oxidative stress is a widely accepted factor in the development and progression of Alzheimer's disease and the ability of cells to control the balance between the generation and quenching of reactive oxygen species is important in combating its potentially damaging effects. Here we introduced 3- (methylthio)-5,6-di-(4-methoxyphenyl)-1,2,4-triazine a derivative of 5,6- Diaryl-3-alkylthio-1,2,4-triazine as a protective agent on PC12 neural cell line against H2O2-induced cell death as determined by MTT test and caspase-3 activity determination. Using western blot technique, we showed that this compound exerts its protective effect by up regulation of HO-1, g-GCS, HSP- 70, Nrf2 and NF-kB. In parallel, H2O2-induced production of malondialdehyde in cultured cells was markedly reduced. Moreover, pre-treatment of thi compound significantly attenuated the changes of catalase and superoxide dismutase activities in H2O2-treated cells. Our study demonstrates that the protection of neuronal cells by 3-(methylthio)-5,6-di-(4-methoxyphenyl)-1,2,4- triazine against oxidative-stress could involve different mechanisms as the regulation of several key intracellular pathways.

 
Keyword(s): 
 
Yearly Visit 6   tarjomyar
 
Latest on Blog
Enter SID Blog