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Paper Information

Title: 

CAN IMMOBILIZATION STRESS INDUCE APOPTOSIS IN PREGNANT RAT HIPPOCAMPI?

Type: POSTER
Author(s): MOUSAVI MARYAM*,GHASEMI RASOUL,MAGHSOUDI NADER,RASTGARI KARIM,ZARIFKAR ASAD ELAH
 
 *PHYSIOLOGY DEPARTMENT, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Stress has been reported to elevate glucocorticoids and to deteriorate hippocampal function and viability. Some studies suggest that immobilization stress results in hippocampal apoptosis in male rats. On the other hand, it has been suggested that pregnant rats are more resistant to neurodegeneration. In this study, we evaluated whether acute and chronic immobilization stress can change glucocorticoid levels and hippocampal viability in pregnant rats. Rats were immobilized from day 14-19 of pregnancy in a restrainer; 1 or 3 hours each day (chronic stress) or just one episode on day 14 (acute stress). Rats were sacrificed after the last stress episode; blood samples were collected to determine corticosterone level. The hippocampi were collected, lysed and anlaysed via western blot to assess caspase 3 cleavage. Immobilization stress elevated corticosterone level, but did not induce apoptosis. It seems that pregnant rats are more resistant to stress than the male rats.

 
Keyword(s): PREGNANCY, IMMOBILIZATION STRESS, APOPTOSIS, RAT, HIPPOCAMPUS
 
 
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