Paper Information

Title: 

EXERCISE AMELIORATES THE UP-REGULATION BRAIN-DERIVED NEUROTROPHIC FACTOR AND APOPTOSIS IN HIPPOCAMPUS OF DIABETIC RATS

Type: POSTER
Author(s): SALEHI IRAJ,MOHAMMADI MOSTAFA,SARIHI A.A.R.,MALAKOUTI SEYED MANSOUR
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background: Oxidative stress, as an outcome of diabetes, plays a role in both pathogenesis and numerous pathophysiological mechanisms that trigger diabetic complications. Brain- Derived Neurotrophic Factor (BDNF) promotes plasticity and survival of synapses and neurons in CNS and protects it against insults. In this study, we evaluated mechanism of effect regular exercise in prevent of diabetes complication in the hippocampus of streptozotocin-induced diabetic rat.
Material and method: 48 male wistar rats were divided into four groups (control, non diabetic exercise, diabetic and diabetes exer cise). Diabetes was induced by injection of single dose of Streptozotocin (50mg.Kg-1, i.p). Exercise was performed for 8 weeks and one hour every day. The antioxidant enzymes (SOD, GPX, CAT and GR) and oxidant indexes with BDNF protein and its mRNA and apoptosis were measured in hippocampus of rats.
Results: A significant decrease in antioxidant enzymes activities and increase MDA level were observed in diabetic rats. In response to exercise antioxidant enzymes activities increased. In contrast, MDA level decreased in diabetic rats. Induction of diabetes caused an increase of BDNF protein and its mRNA expression. In response to exercise, BDNF protein and its mRNA expression reduced in hippocampus in diabetic rats.
Conclusion: Exercise ameliorates oxidative stress induced BDNF gene expression up regulation and protects of hippocampus against oxidative stress damage in diabetic rat.

 
Keyword(s): BDNF, OXIDATIVE STRESS, EXERCISE
 
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